As noted, in addition to these conditions, there is growing recognition that hypermobility is associated with the presence of one or more neurodevelopmental conditions, including autism and ADHD ( 17– 19). Individuals with EDS are reported to be 7.4 times (95% CI: 5.2–10.7) more likely to be autistic than a comparison group ( 18). Autistic children were shown to have greater mobility of joints (maximum passive joint mobility in degrees of angle were measured for a finger, wrist, elbow, and ankle) compared to a matched comparison group ( 20). The association between autism and joint hypermobility syndrome/hEDS is further illustrated in a series of case studies ( 21), highlighting the need for more systematic research for robust characterization of these links ( 17). ADHD is also associated with GJH: One study reported generalized hypermobility in 32% of 54 patients with ADHD, compared to 14% of a comparison group ( 22). Another study reported the prevalence of GJH to be 74% in 86 children with ADHD, compared to 13% of a comparison group ( 23). Moreover, in a population-based matched cohort study in Sweden ( n = 1,771), individuals with EDS were 5.6 times (95% CI: 4.2–7.4) more likely to have an ADHD diagnosis than those without EDS ( 18). Lazarus S, Okolorie GU (2019) The bifurcation of the Nigerian cybercriminals: Narratives of the Economic and Financial Crimes Commission (EFCC) agents. Telemat Informat 40:14–26

Green V, O’Reilly M, Itchon J, Sigafoos J (2005) Persistence of early emerging aberrant behavior in children with developmental disabilities. Res Dev Disabil 26:47–55 Malfait F, Belmont J, Berglund B et al (2017) The 2017 international classification on the Ehlers–Danlos syndromes. Am J Med Genet 175C:148–157 Concerning HDCTs, the work by Blair et al. ( 36) which examined comorbidity among Mendelian and complex diseases by mining the medical records of over 110 million patients, observed significant clinical comorbidities between Marfan syndrome (i.e., HDCTs characterized by marfanoid habitus, aortic aneurysm, and ectopia lentis) and neuropsychiatric conditions such as ASD. These results had not been reported before. Recently, Balasubramanian et al. ( 37) reported a higher incidence of ASD in people with Osteogeneses Imperfecta (i.e., HDCTs characterized by brittle bones and blue sclerae). Ten out 102 patients in their cohort have ASD while in the general population ASD is estimated of 1 in 100.Gillberg C (2010) The ESSENCE in child psychiatry: early symptomatic syndromes eliciting neurodevelopmental clinical examinations. Res Dev Disabil 31:1543–1551 CGAP conducted nationally representative surveys of smallholder households, along with financial diary research, in six countries between 2013 and 2017. These countries were: Bangladesh, Côte d'Ivoire, Mozambique, Nigeria, Tanzania, and Uganda. The research covers the agricultural and financial lives of smallholders, including their agricultural and non-agricultural revenue sources, financial practices and tools, mobile phone use, and other factors that are useful in segmenting markets, identifying needs, and designing appropriate financial services. Ho HTN, Luong HT (2022) Research trends in cybercrime victimization during 2010–2020: a bibliometric analysis. SN Soc Sci 2(1):1–32 Montracon Part of the Ballyvesey Group, Doancaster based business manufacturers a range of trailers including low loaders. There is less chance of the tissue dying, as it remains connected to the person’s blood and nerve supply.

Kigerl A (2012) Routine activity theory and the determinants of high cybercrime countries. Soc Sci Comput Rev 30(4):470–486 Phillips K, Davidson JC, Farr RR, Burkhardt C, Caneppele S, Aiken MP (2022) Conceptualizing cybercrime: definitions, typologies and taxonomies. Forensic Sci 2(2):379–398 Solano PC, Peinado AJR (2017) ‘Socio-economic factors in cybercrime: Statistical study of the relation between socio-economic factors and cybercrime’. 2017 International Conference On Cyber Situational Awareness, Data Analytics And Assessment (Cyber SA): IEEE, pp. 1–4 Agent networks provide a vital link between low-income consumers and digital financial services providers, allowing for cash-in and cash-out (CICO) transactions. Given that rural areas are home to the bulk of the world's financially excluded and underserved population, expanding rural CICO agent networks is crucial to achieving greater financial inclusivity. Fairchild, B., et al. (2020). Safety and efficacy of smooth surface tissue expander breast reconstruction.

Publisher's Note

Mallorquí-Bagué N, Garfinkel SN, Engels M, Eccles JA, Pailhez G, Bulbena A, Critchley HD (2014) Neuroimaging and psychophysiological investigation of the link between anxiety, enhanced affective reactivity and interoception in people with joint hypermobility. Front Psychol 14(5):1162 In addition, we found that the body image of college students had a moderating effect on PA and anxiety, but not on depression. Dissatisfaction with one’s body image is a common problem among college students, especially female college students [ 70]. It has also been found to be highly correlated with social body anxiety [ 71]. The results show that with the increase in body image levels, the relationship between PA and anxiety strengthens. This may be because body image itself and anxiety are significantly related [ 72], as important factors. Body image plays a synergistic role in reducing anxiety with PA, so the more positive the body image is, the better the effect of PA on reducing anxiety is. Furthermore, our study find that college students’ body image is significantly correlated with depression and anxiety, which may be due to mentally healthy college students having a better knowledge of their bodies. Unfortunately, our results show that although the correlation between body image and anxiety is higher than that of depression, the difference is small. The association between PA, body image, depression and anxiety should be further explored through longitudinal or interventional studies in the future. Orthostatic intolerance is a particular common expression of intermittent cardiovascular autonomic dysfunction in people with hypermobility conditions; symptoms such as light-headedness occur upon standing upright and can be relieved by recumbence ( 29). Symptoms of orthostatic intolerance can be debilitating ( 12). Associated syncope, fatigue, and migraines add to clinical burden and reduce quality of life ( 30). Castori M, Dordoni C, Valiante M et al (2014) Nosology and inheritance pattern(s) of joint hypermobility syndrome and Ehlers–Danlos syndrome, hypermobility type: a study of intrafamilial and interfamilial variability in 23 Italian pedigrees. Am J Med Genet A 164A:3010–3020 Lusthaus J, Varese F (2021) Offline and local: the hidden face of cybercrime. Policing J Policy Pract 15(1):4–14

If the procedure is occurring separately from the mastectomy, the surgery will usually last 1–2 hours. Chapelle, C. A., Cotos, E., & Lee, J. (2015). Validity arguments for diagnostic assessment using automated writing evaluation. Language Testing, 32(3), 385–405.

Conflict of Interest

Cairney J, Veldhuizen S, Szatmari P (2010) Motor coordination and emotional-behavioral problems in children. Curr Opin Psychiatry 23:324–329 The surface of tissue expanders can be textured or smooth. People using them for breast reconstruction purposes may wish to talk with a surgeon about opting for a smooth surface tissue expander. Jenny L. L. Csecs 1,2 † Valeria Iodice 3,4 † Charlotte L. Rae 5 Alice Brooke 1,2 Rebecca Simmons 6 Lisa Quadt 1,2 Georgia K. Savage 1,2 Nicholas G. Dowell 1,7 Fenella Prowse 1,8 Kristy Themelis 1,9 Christopher J. Mathias 3,4,10 Hugo D. Critchley 1,2,6 Jessica A. Eccles 1,2,6 * A regulatory sandbox is a framework established by a regulatory body that allows innovators to perform live experiments in a controlled setting under the observation of a regulator. Regulatory sandboxes can help regulators to make faster and better informed decisions on how to appropriately regulate (and supervise) new services and providers reaching the marketplace.